Jim DelProposto

About

I am a research scientist with extensive experience at the University of Michigan, where I have contributed to multidisciplinary programs spanning structural biology, high-throughput screening, and early-stage drug discovery. My work bridges the gap between fundamental protein science and translational research, combining hands-on laboratory expertise with computational approaches to accelerate the identification of novel therapeutics.

With 12+ peer-reviewed publications in leading journals and a U.S. patent in protein purification technology, I am passionate about applying rigorous biophysical and biochemical methods to solve complex biological problems.

Core Expertise

A diverse skill set developed over years of interdisciplinary research in academia and collaborative drug discovery programs.

Protein Expression & Purification

Design and optimization of recombinant protein expression systems and multi-step purification workflows. Inventor of patented purification tag technology (US 8,357,511).

X-ray Crystallography & Structural Biology

Protein crystallization, X-ray diffraction data collection, structure determination, and structure-guided ligand design for drug discovery campaigns.

High-Throughput Screening & Assay Development

Development and execution of biochemical and biophysical assays (BLI, SPR, fluorescence polarization) for large-scale compound screening and hit validation.

Drug Discovery & Computational Chemistry

Protein-ligand interaction analysis, PROTAC degrader development, laboratory automation, and computational chemistry support for medicinal chemistry programs.

Publications & Research

Over a 15-year research career, I have co-authored 12+ publications in high-impact journals including Journal of Medicinal Chemistry, Science, PLoS Pathogens, and Nature Communications. My research spans protein–protein interaction inhibitors, PROTAC-mediated targeted protein degradation, structural biology of viral and bacterial proteins, and novel purification methodologies.

I also hold U.S. Patent 8,357,511 — “Protein purification tags and uses thereof.”

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